Philips ISPM

Summary:

Philips IntelliSpace Precision Medicine (ISPM) includes genomics database at Stanford. This data is geared towards identifying genetic mutations that can be targeted for precision medicine, with the goal of improving therapeutic outcomes through personalized treatment strategies. As of August 2025, 20,090 STAMP tests were ordered for 14,106 patients.

Test Types N_Case Min_Date Max_Date
Foundation One Ckb Test 3,437 2001-07 2025-07
Stanford Stamp Test 16,653 2018-03 2025-07
Total number of ordered tests: 20,090

Note: Additional FoundationOne (F1) test data was backfilled between the May release and the Philips export dated from 07/13/25 to 08/05/25, which was used for the August release. More data is expected in future releases

🧬 Data Components

  • Diagnoses Orders: includes patients who had the test ordered
  • Aberration: records if a genetic aberration is found in the STAMP panel tests

📊 Data Volume

  • Patients Count: 14,106
  • Patients with Aberration Cases: 13,764
  • Patients with Pathogenic Cases: 8,073

Aberration Metrics:

The aberration table provides a structured overview of genetic changes, categorizing them into specific types and broader classes. Each entry in the table includes the following key components:

  • Aberration Types: An aberration type describes a specific change to DNA. These are specific alterations in DNA that can affect gene function and contribute to various diseases. Each type represents a distinct change, such as missense variant, deletions, duplications, or point mutations.

  • Chromosomes: This field indicates the chromosomal location of the gene associated with the aberration. For example if a gene is located on chromosome 17, it will be presented as “chr17”.

  • HGNC Gene and Detected Mutations: The HGNC (HUGO Gene Nomenclature Committee) provides standardized names for human genes. Detected mutations refer to specific changes found in these genes that may be important for specific therapies, such as gene therapy or personalized medicine.

The following analysis displays the genes distribution of positive aberration above 200 cases.

HGNC Gene Distribution:

Summary Table of HGNC Gene Distribution

Genes Distribution by Chromosomes

Distribution of Genes by Aberration Type

Thoracic cancer patients are identified based on their primary site descriptions in the Neural Frame diagnoses data, which include diagnoses of lung, bronchus, or thymus cancers.

From 13,880 unique thoracic patients, 2,390 patients were included in Philips ISPM database with 2,362 aberration cases.

Distribution of Gene Types by Pathogenicity

KRAS Mutations

The KRAS gene is a critical component in cell signaling pathways that regulate cell growth and division, and mutations in this gene are frequently associated with various cancers including thoracic cancers. Among patients with thoracic cancer with mutations in the KRAS gene, the most common amino acid alterations occurring are listed as follow:

Source Codes:

The source codes for this page can be found here, and the sql queries that support the metrics can be found here.